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Use of Plavix following a partial occlusion of a branch artery in left retina. Other than having to be careful not to scrape or cut myself in the garden, my main side effect is occasional bleeding in the white of my right eye. I had glaucoma surgery in my right eye. I have asked my internist if it would be okay to discontinue use of Plavix and the answer was no. Not based on my history of a clot in my left eye which I was told could have caused a stroke. My doctor says that Plavix has the least side effects of the available blood thinner medications.
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Their risk of heart attack, stroke or death was about 7 percent versus 8 percent for those taking aspirin alone.

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Clopidogrel's benefit is primarily in those who smoke cigarettes, with only slight benefit in those who do not.

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Drinking alcohol to protect against heart disease is not advocated by the American Heart Association and other organizations because of the potential for addiction and other serious problems, such as car accidents and the increased risk of hypertension, liver disease, breast cancer, and weight gain.

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Studies show that more than 20% of the population does not metabolize clopidogrel completely -- these "non-responder" patients may be treated with increased dosages, or possibly a different antiplatelet drug, such as Effient (prasugrel) or Brilinta (ticagrelor) which do not need to be metabolized first.

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It is not clear at all whether remaining on DAPT would have prevented this, because the thrombosis may be due to other causes, such as something called late-remodeling (where the artery wall slowly moves outward from the stent) etc.

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