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Use of Plavix following a partial occlusion of a branch artery in left retina. Other than having to be careful not to scrape or cut myself in the garden, my main side effect is occasional bleeding in the white of my right eye. I had glaucoma surgery in my right eye. I have asked my internist if it would be okay to discontinue use of Plavix and the answer was no. Not based on my history of a clot in my left eye which I was told could have caused a stroke. My doctor says that Plavix has the least side effects of the available blood thinner medications.
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But it does have to do with preventing blood clots inside the stent, also called stent thrombosis, which is very serious (30% of the time it causes a fatal heart attack!

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Influence of genetic and non-genetic factors on the plasma concentrations of the clopidogrel metabolite (SR26334) among Chinese patients.

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If the colonoscopy must be done before August 2012, perhaps your cardiologist can devise a "bridging strategy" with a different drug.

Their risk of heart attack, stroke or death was about 7 percent versus 8 percent for those taking aspirin alone.

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Clopidogrel's benefit is primarily in those who smoke cigarettes, with only slight benefit in those who do not.

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Drinking alcohol to protect against heart disease is not advocated by the American Heart Association and other organizations because of the potential for addiction and other serious problems, such as car accidents and the increased risk of hypertension, liver disease, breast cancer, and weight gain.

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Studies show that more than 20% of the population does not metabolize clopidogrel completely -- these "non-responder" patients may be treated with increased dosages, or possibly a different antiplatelet drug, such as Effient (prasugrel) or Brilinta (ticagrelor) which do not need to be metabolized first.

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It is not clear at all whether remaining on DAPT would have prevented this, because the thrombosis may be due to other causes, such as something called late-remodeling (where the artery wall slowly moves outward from the stent) etc.

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