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Among subjects with bipolar II disorder, there was a nonsignificant trend toward a better response in the patients receiving a mood stabilizer plus placebo than in those receiving a mood stabilizer plus an antidepressant.

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An additional male volunteer (maintained on placebo) left the study during the first in-patient week complaining of stomach acidity.

One female and six male research volunteers averaging 26 1 years (mean SD) completed the 58-day experiment.

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Younger children, especially those receiving enzyme-inducing drugs, will require larger maintenance doses to attain targeted total and unbound valproate concentrations.

Divalproex sodium delayed-release tablets are a valproate and are indicated for the treatment of the manic episodes associated with bipolar disorder.

To evaluate the long-term safety and tolerability of divalproex sodium extended-release in the prophylaxis of migraine headaches in adolescents.

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Epival is a Canadian brand name for divalproex sodium, a valproic acid derivative.

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To provide information regarding the effects of in utero exposure to divalproex sodium, healthcare providers are advised to recommend that pregnant patients taking divalproex sodium enroll in the NAAED Pregnancy Registry.

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