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For obese adolescents older than age 12 years, the addition of orlistat to a comprehensive lifestyle weight loss program improved weight loss and BMI (Grade A); however, use of this medication had a high rate of GI side effects.

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Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the Diabetes Heart Study.

The combined use of fenofibrate tablets and HMG-CoA reductase inhibitors should be avoided unless the benefit of further alterations in lipid levels is likely to outweigh the increased risk of this drug combination.

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In the absence of significant physical activity and lifestyle modifications, it would seem that appropriate pharmaceutical options are needed to properly manage markers of CVD-related risk in persons with SCI.

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CVD, a more common cause of death in populations with diabetes than microvascular complications, is less clearly impacted by levels of hyperglycemia or the intensity of glycemic control.

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For example, the Dietary Approaches to Stop Hypertension diet, which encourages the intake of fruits, vegetables, and low-fat dairy products, particularly when those foods are combined with sodium restriction, was associated with substantial improvements in blood pressure ().

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Treatment of patients with Type IV hyperlipoproteinemia and elevated triglycerides often results in an increase of low density lipoprotein (LDL) cholesterol (see Table 2).

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Approximately 20% of HDL uptake of cellular cholesterol occurs via ABCG1.

Bile acid-binding sequestrants may be used in combination with a statin for patients who fail to meet LDL?

This evidence review for blood pressure for these guidelines was therefore limited to studies published between January 1, 2003, and June 30, 2007, with the addition of selected studies through June 30, 2008, identified by the Expert Panel that meet all the criteria for inclusion.

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Trials like the Collaborative Atorvastatin Diabetes Study (CARDS), proved beyond doubt that patients with type 2 diabetes and other risk factors for CVD should be treated with a statin, apparently disregarding their initial LDL cholesterol level ().

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Fibric acid derivatives in cardiovascular disease prevention: results from the large clinical trials.

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LDL-lowering therapy and treatment of LDL cholesterol to goal after triglyceride-lowering therapy.

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There is a risk of severe bleeding in patients taking fenofibrate while on Coumadin (warfarin sodium) anticoagulation therapy.

It is also the standard treatment for patients with acalculous cholecystitis (gallbladder inflammation without stones).

A generic drug is usually called by the name of the active ingredient while a manufacturer uses a brand name.

Other lipid lowering agents that are not statins but work to treat elevated cholesterol and triglycerides levels include Zetia (ezetimibe), Lopid (gemfibrozil), Tricor (fenofibrate), niacin containing pharmaceuticals like Niaspan, and bile acid sequestrants like Questran (cholestyramine) and Colestid (colestipol).

Among the most prevalent multiple risk combinations are the use of tobacco with one other risk factor, and the development of obesity which is often associated with insulin resistance, elevated triglycerides, reduced HDL cholesterol and elevated blood pressure, a combination known as the metabolic syndrome in adults.

Diabetes may be identified anywhere along a spectrum of clinical scenarios ranging from a seemingly low-risk individual who happens to have glucose testing, to a higher-risk individual whom the provider tests because of high suspicion of diabetes, to the symptomatic patient.


Serum lipids and endometrial cancer risk: Results from the HUNT-II study.

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The Expert Panel elected to use the AHA guideline as the template for developing recommendations for children with conditions like diabetes that predispose them to very accelerated atherosclerosis since the evidence review identified only a very small number of studies addressing these conditions in a randomized trial format.

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Common Variants in the ATP-binding Cassette Transporter 1 Gene with Decreased HDL-Cholesterol Levels and Coronary Artery Disease.

To examine the effect of missing data on our conclusions, we conducted unadjusted analyses and adjusted analyses (using the primary models) of the proportions of patients with missing data in each treatment group.

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The letters A, B, C, or E show the evidence level that supports each recommendation.

This would especially be the case if this can be achieved with few drugs and without side effects of therapy.

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The main purpose of this study was to investigate the role of fenofibrate on endothelial function, assessed by vascular studies and soluble E-selectin (sE-selectin), and on plasma MPO in patients with T2DM without previous use of lipid-lowering medication.

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