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Tenofovir, a widely prescribed antiretroviral medication for treatment of HIV-1 infection, is infrequently associated with renal dysfunction and biopsy findings of acute tubular necrosis.

The VAS can be useful for documenting baseline symptoms as well as responses to therapy.

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Tenofovir is available under the brand name Viread in 300 mg oral tablets.

Requires dose adjustment in patients with impaired renal function; use with extreme caution.

However, many additional mutations at these 55 positions that occur commonly in persons receiving antiretroviral drugs have not been studied.

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ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED.

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When the researchers compared people assigned to take Truvada with those assigned to take the placebo, they found that people who were given Truvada had lower HIV infection rates compared to people who were given placebo.

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If you are also taking didanosine -coated tablets, take both products either on an empty or with a light meal.

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National Institute of Allergy and Infectious Diseases (NIAID): News Release, dated March 4, 2013.

Insertions at this position act in a manner similar to the TAMs by causing ATP-mediated primer unblocking but they also destabilize the dead-end complex described above and thus cause more phenotypic resistance to the whole NRTI class than observed with the TAMs alone.

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How much the other drugs in the regimens contributed to these findings is unclear, and true head-to-head trials are still warranted.

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These differences have no effect on the medical action of the drug whatsoever.

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However, the authors recommend that their findings be interpreted with caution due to the high risk of bias of the studies included in the analysis.

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For patients with impaired renal function, a reduced dose may be necessary.

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Recently, the answer has been that earlier treatment is recommended.

Among the 45 subjects receiving VIREAD, the most frequently reported treatment-emergent adverse reactions of any severity were abdominal pain (22%), nausea (20%), insomnia (18%), pruritus (16%), vomiting (13%), dizziness (13%), and pyrexia (11%).

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Post hoc analyses from the open-label extension of the iPrex study have suggested that there were no incident HIV-1 infections among participants with an intracellular level of tenofovir diphosphate that was associated with continuous receipt of at least 4 tablets of TDF-FTC per week.

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