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My father has been on Capecitabine for almost two years now after he was diagnosed with stage three colorectal cancer about 4 years ago. As far as side effects, weight gain seems to be most problematic for him. But in general the medication is better than many medications we have tried before. Anyway the weight gain is not too dramatic and is fully acceptable taking into account the positive effect from the medication. Capecitabine turned out to be very effective has worked perfectly well in reducing his tumour. No my father looks much healthier and he feels better as well. He can feel the taste of food again, he feels the smells and his hair started growing again. To my mind Capecitabine is an excellent solution for cancer sufferers.
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The third patient experienced stable disease and improved well-being even though chemotherapy had been deemed highly unlikely to be beneficial (patient 13).

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The benefits of fluorouracil-based adjuvant chemotherapy in reducing the risk of relapse and prolonging survival in patients with resected colon cancer are well established, particularly in stage III disease.

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Therefore, reduction of fluoropyrimidine dosage in patients with these variants may prevent severe and possibly life-threatening toxicities.

Most of these people will have passed away by the end of the first year.

Dudley ME, Wunderlich JR, Yang JC, Sherry RM, Topalian SL, Restifo NP, Royal RE, Kammula U, White DE, Mavroukakis SA, Rogers LJ, Gracia GJ, Jones SA, Mangiameli DP, Pelletier MM, Gea-Banacloche J, Robinson MR, Berman DM, Filie AC, Abati A, Rosenberg SA (2005) Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma.

PREGNANCY and BREAST-FEEDING: Capecitabine has been shown to cause harm to the fetus.

Three patients (patients 10, 11, 13) had unusually favorable experiences that were deemed highly unlikely to result from chemotherapy alone (probability much less than 33%).

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CAPIRI-Bev has a less favourable toxicity profile, requiring dose reductions, in order to be considered as an option in first-line treatment of patients with mCRC.

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In addition, the AUC of in tumor via capecitabine dosing was 18- to 32-fold higher than via direct 5-FU dosing, demonstrating that capecitabine is efficiently converted to 5-FU in the tumors.

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As reported by Vasen et al in the Journal of Clinical Oncology, surveillance for pancreatic ductal adenocarcinoma in high-risk individuals appears to be of benefit in individuals at risk due to CDKN2A mutation, with the advantage being less clear among individuals at risk due to familial clustering of pancreatic cancer.

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Use of Cytotoxic Chemotherapy in Metastatic Breast Cancer: Putting Taxanes in Perspective.

The Impact of Drug Vintage on Patient Survival: A Patient-Level Analysis Using Quebec's Provincial Health Plan Data.

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Biomarker evaluation in the phase III, placebo (P)-controlled, randomized BeTa trial of bevacizumab (B) and erlotinib (E) for patients (Pts) with advanced non-small cell lung cancer (NSCLC) after failure of standard 1st line chemotherapy: correlation with treatment outcomes.

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Hoff P, Tabernero J, Shen L, Ohtsu A, Yu R, Szado T, Kang Y (2013) Pertuzumab, trastuzumab and chemotherapy in HER2-positive metastatic gastric or gastro-oesophageal junction cancer: an international phase III study (JACOB).

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